Introduction Triple-negative breast cancers need to be refined in order to identify therapeutic
subgroups of patients. Methods We conducted an unsupervised analysis of microarray gene…

Objectives To analyze long‐term cognitive status and function after cochlear implantation in
profoundly deaf individuals. Design Prospective observational longitudinal study. Setting …

Purpose The extant response shift definitions and theoretical response shift models, while
helpful, also introduce predicaments and theoretical debates continue. To address these …

During the past decade, health technology assessment bodies have faced new challenges
in establishing the benefits of new drugs for individuals and health-care systems. A topic of …

In France, decisions for reimbursement taken by the Ministry of Health are based on appraisal
by an independent Health Technology Assessment body (HTAb): the ‘Haute Autorité de …

Objective To assess through multivariate analysis the clinical pre- and intraoperative factors
of facial nerve outcomes at day 8 and 1-year recovery of facial palsy, as compared with day …

Purpose Some IRT models have the advantage of being robust to missing data and thus can
be used with complete data as well as different patterns of missing data (informative or not). …

Background Patient-Reported Outcomes (PROs) are standardized questionnaires used to
measure subjective outcomes such as quality of life in healthcare. They are considered …

Background Using a real dataset, we highlighted several major methodological issues
raised by the estimation of the Minimal Clinically Important Difference (MCID) of a Patient-…

Background Disease activity may change over time in axial spondyloarthritis (axSpA). The
objectives were to identify patterns of disease activity evolution in patients with early axSpA. …