Atipamezole is an α 2 ‐adrenoceptor antagonist with an imidazole structure. Receptor binding
studies indicate that its affinity for α 2 ‐adrenoceptors and its α 2 /α 1 selectivity ratio are …

Studies on animal models of stress, anxiety, aggression, and sensorimotor gating have
linked specific monoamine neurotransmitter abnormalities to the cognitive and behavioral …

Background Cerebral ischemia induces a massive release of norepinephrine associated with
neuronal death in the brain. It has been demonstrated that alpha2-adrenoceptor agonists …

The present study was undertaken to explore the possible neuroprotective effect of the selective
α 2 -adrenoceptor agonist, dexmedetomidine in a rat model of focal cerebral ischemia. …

α 2 -Adrenergic receptors (α 2 -ARs) regulate many physiological functions and are targets
for clinically important antihypertensive and anesthetic agents. Three human and mouse …

The present study characterized the behavioral effects of the selective α 2 -adrenoceptor
antagonist, atipamezole, in a rat model of focal cerebral ischemia. Atipamezole (1 mg/kg, sc) or …

In the present study we evaluated the α 1 - and α 2 -adrenoceptor subtype binding, central α
2 -adrenoceptor antagonist potency, as well as effects on brain neurochemistry and …

The α 2 ‐adrenoceptors (ARs) are important modulators of a wide array of physiological
responses. As only a few selective compounds for the three α 2 ‐AR subtypes (α 2A , α 2B and α …

The activation of 5‐HT 2A receptors has been shown to enhance the probability of premature
responding, regarded as a form of motor impulsive behaviour. At the behavioural level, the …

The present experiments were designed to examine the effects of alpha-1 adrenergic stimulation
and inhibition on memory encoding and to investigate whether the alpha-1 adrenergic …