Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium‐…

Objective: To investigate and measure the functional significance of altered P2Y12 expression
in the context of human microglia activation. Methods: We performed in vitro and in situ …

We report a novel model in which remote activation of peripheral nociceptive pathways in
transgenic mice is achieved optogenetically, without any external noxious stimulus or injury. …

Mutations in the parkin gene result in an autosomal recessive juvenile-onset form of Parkinson's
disease. As an E3 ubiquitin-ligase, parkin promotes the attachment of ubiquitin onto …

In this report, we have tested the hypothesis that brain-derived neurotrophic factor (BDNF) is
an anterograde neurotrophic factor in the CNS and have focused on central noradrenergic …

Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive
fields in the skin, raising the question of how pruriception and nociception are coded and …

P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory
transduction, neuro-immune communication and inflammatory response. P2X receptors …

Activation of microglia has been implicated in many neurological conditions including
Alzheimer's disease and neuropathic pain. Recent studies provide evidence that P2X ATP …

We report a novel transgenic mouse model in which the terminals of peripheral nociceptors
can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation …

P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium. There is
increasing evidence that this homomeric purinoceptor, which is expressed in several neuronal …