Role of the supplementary motor area and the right premotor cortex in the coordination of bimanual finger movements

N Sadato, Y Yonekura, A Waki… - Journal of …, 1997 - Soc Neuroscience
To obtain a better understanding of the cortical representation of bimanual coordination, we
measured regional cerebral blood flow (rCBF) with 15 O-labeled water and positron …

Characterization of acetate metabolism in tumor cells in relation to cell proliferation: acetate metabolism in tumor cells

M Yoshimoto, A Waki, Y Yonekura, N Sadato… - Nuclear medicine and …, 2001 - Elsevier
To reveal the metabolic fate of acetate in neoplasms that may characterize the accumulation
patterns of [1- 11 C]acetate in tumors depicted by positron emission tomography. Four tumor …

Neural networks for generation and suppression of alpha rhythm: a PET study

…, T Oohashi, E Nishina, Y Fuwamoto, A Waki… - …, 1998 - journals.lww.com
TO study neuronal activities that influence the generation of the alpha rhythm, we used positron
emission tomography and simultaneous recording of the electroencephalogram (EEG) in …

Regional cerebral blood flow changes in human brain related to ipsilateral and contralateral complex hand movements–a PET study

…, N Sadato, E Naito, A Waki… - European Journal of …, 1998 - Wiley Online Library
The purpose of this study was to investigate the cortical motor areas activated in relation to
unilateral complex hand movements of either hand, and the motor area related to motor skill …

Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent Cu-diacetyl-bis(N 4-methylthiosemicarbazone) (Cu-ATSM) in tumor …

A Obata, E Yoshimi, A Waki, JS Lewis, N Oyama… - Annals of nuclear …, 2001 - Springer
The retention mechanism of the novel imaging/radiotherapeutic agent, Cu-diacetyl-bis(N 4 -methylthiosemicarbazone)
(Cu-ATSM) in tumor cells was clarified in comparison with that in …

The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation

Y Yoshii, A Waki, K Yoshida, A Kakezuka, M Kobayashi… - Biomaterials, 2011 - Elsevier
Two-dimensional (2D) cell cultures are essential for drug development and tumor research.
However, the limitations of 2D cultures are widely recognized, and a better technique is …

[HTML][HTML] Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy …

…, N Oyama, Y Hasegawa, Y Kiyono, R Nishii, A Waki… - PloS one, 2013 - journals.plos.org
Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression
is associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show …

Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism

…, H Yoshii, T Mori, Y Kiyono, A Waki… - Cancer …, 2009 - Wiley Online Library
Understanding tumor‐specific metabolism under hypoxia is important to find novel targets for
antitumor drug design. Here we found that tumor cells expressed higher levels of cytosolic …

Evaluation of62Cu labeled diacetyl-bis(N 4-methylthiosemicarbazone) as a hypoxic tissue tracer in patients with lung cancer

…, Y Fujibayashi, Y Yonekura, MJ Welch, A Waki… - Annals of nuclear …, 2000 - Springer
62 Cu labeled diacetyl-bis(N 4 -methylthiosemicarbazone) ( 62 Cu-ATSM) has been proposed
as a generator-produced, positron-emitting tracer for hypoxic tissue imaging. From basic …

Basis of FLT as a cell proliferation marker: comparative uptake studies with [3H] thymidine and [3H] arabinothymidine, and cell-analysis in 22 asynchronously growing …

J Toyohara, A Waki, S Takamatsu, Y Yonekura… - Nuclear medicine and …, 2002 - Elsevier
The usefulness of radiolabeled 3′-fluoro-3′-deoxythymidine (FLT), a thymidine derivative
with affinity to cytoplasmic thymidine kinase 1 (TK 1 ), as a tumor proliferation marker was …