Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Huntington's disease (HD) is a progressive, fatal neurological condition caused by an expansion
of CAG (glutamine) repeats in the coding region of the Huntington gene. To date, there …

N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs are …

Disease-modifying therapies that slow or halt the progression of Parkinson's disease are an
unmet clinical need. Many hypotheses have been put forward to explain the pathogenesis of …

Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has
implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is …

A Saskatchewan multi-incident family was clinically characterized with Parkinson disease (PD)
and Lewy body pathology. PD segregates as an autosomal-dominant trait, which could …

Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The
most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 …

The NMDAR plays a unique and vital role in subcellular signaling. Calcium influx initiates
signaling cascades important for both synaptic plasticity and survival; however, overactivation …

Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia (FTD),
but the role of progranulin in the brain is poorly understood. To investigate the role of …

… A survey of the immunoreacted tissue sections was performed by two independent operators
(Austen J. Milnerwood, Payam Rezaie) to verify specific immunoreactivity in duplicate …