Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons,
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …

The neurobiological basis of autism spectrum disorder (ASD) remains poorly understood.
Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized …

Background As regulators of gene expression, microRNAs (miRNAs) play a key role in the
transcriptional networks of the developing human brain. Circulating miRNAs in the serum and …

Ever since their discovery, the telomeres and the telomerase have been topics of intensive
research, first as a mechanism of cellular aging and later as an indicator of health and …

Background Mitochondrial dysfunction (MtD) has been observed in approximately five
percent of children with autism spectrum disorders (ASD). MtD could impair highly energy-…

Mitochondrial dysfunction ( MtD ) and abnormal brain bioenergetics have been implicated
in autism, suggesting possible candidate genes in the electron transport chain ( ETC ). We …

Mitochondria have a crucial role in brain development and neurogenesis, both in embryonic
and adult brains. Since the brain is the highest energy consuming organ, it is highly …

Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction
of axon-guidance signaling is thought to underlie the microstructural abnormalities of …

Autism is a pervasive developmental disorder diagnosed in early childhood. Abnormalities
of serotonergic neurotransmission have been reported in autism. Serotonin transporter (5-…

Background: Synaptic dysfunction has been shown to be involved in the pathogenesis of
autism. We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved in …