Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …

Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

This article reviews prefrontal cortical biology as it relates to pathophysiology and genetic
risk for schizophrenia. Studies of prefrontal neurocognition and functional neuroimaging of …

The constellation of major phenomena associated with schizophrenia (eg, postpubertal
onset, congenital hippocampal area damage, cortical functional deficits, limbic dopamine (DA) …

Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

Previous investigations have combined transcriptional and genetic analyses in human cell
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …

Two of the favorite hypotheses of schizophrenia research — maldevelopment of cerebral
cortex and malfunction of brain dopamine systems — have often seemed difficult to reconcile. …

Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated
SNPs are noncoding, and their functional implications remain unknown. We …

The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions
to mature. To investigate the role of epigenetics in the development of PFC, we examined …

Neonatal excitotoxic hippocampal damage in the rat results in postpubertal onset of a variety
of abnormal behaviors related to excessive dopaminergic transmission in the mesolimbic/…