Early treatment of acute HIV-1 infection followed by treatment interruptions has shown promise
for enhancing immune control of infection 1 , 2 , 3 . A subsequent loss of control, however, …

Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are
being investigated for their widespread health benefits. These benefits have generally been …

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as
potential molecular therapeutic agents for the treatment of cancer. Here we describe novel 2-…

Review of clinical data from 350 patients with small-cell lung cancer (SCLC) revealed
hyponatremia (sodium less than 130 mEq/L) attributable to the syndrome of inappropriate …

In the past 15 years, fragment-based lead discovery (FBLD) has been adopted widely
throughout academia and industry. The approach entails discovering very small molecular …

Urodele amphibians, like the newt, are the “champions of regeneration” as they are able to
regenerate many body parts and tissues. Previous experiments, however, have suggested …

Heat shock protein (HSP) 60 is a mitochondrial and cytosolic protein. Previously, we reported
that HSP60 doubled in end-stage heart failure, even though levels of the protective HSP72 …

Introduction Ankle fractures are among the most common injuries of the lower extremity
encountered by orthopaedic surgeons. With increasing population age and osteoporosis, the …

The targeting of RNA for the design of novel anti-viral compounds has until now proceeded
largely without incorporating direct input from structure-based design methodology, partly …

The targeting of RNA for the design of novel anti-viral compounds represents an area of
vast potential. We have used NMR and computational methods to model the interaction of a …