G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to
hormones, neurotransmitters and environmental stimulants, and so have great potential as …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …

Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among
the most used clinical drugs to relieve severe pain. These prototypical opioids produce …

G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …

The α 2 and β 2 adrenergic receptors, both of which are activated by epinephrine, but which
can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on …

The β 2 -adrenergic receptor (β 2 AR) is a well-studied prototype for heterotrimeric guanine
nucleotide–binding protein (G protein)–coupled receptors (GPCRs) that respond to diffusible …

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response
to natural and synthetic ligands. Recent crystal structures provide insights into inactive …

G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external
stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein …

Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters
has been hindered by their low natural abundance, inherent structural flexibility, and …

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that
modulate biological function by initiating cellular signalling in response to chemically diverse …