Les fluoropyrimidines restent les molécules anticancéreuses les plus prescrites dans le
traitement des tumeurs solides. Elles induisent des toxicités sévères chez 10–40 % des patients …

Importance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common
presentation of coronavirus disease 2019 (COVID-19). Objective To determine whether …

Background Patients with COVID-19 pneumonia have an excess of inflammation and
increased concentrations of cytokines including interleukin-1 (IL-1). We aimed to determine …

The aim of the study is to explore the contribution of genetic factors related either to drug
metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to variability …

Objective The aim of this study was to investigate the respective influence of genetic and
nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery. …

Background The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26
on digoxin pharmacokinetics has recently been challenged. Objective To clarify the …

Background— Clopidogrel requires metabolic activation by cytochrome P450 2C19 (CYP2C19).
Proton pump inhibitors (PPIs) that inhibit CYP2C19 are commonly coadministered with …

Background Pharmacogenetic determinants of the response of patients to clopidogrel
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …

Tacrolimus is a widely used immunosuppressive drug in organ transplantation. Its oral
bioavailability varies greatly between individuals, and it is a substrate of cytochrome P450 3A (…

The present article summarizes the discussions of the 3rd European Science Foundation–University
of Barcelona (ESF–UB) Conference in Biomedicine on Pharmacogenetics and …