The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs)
are not static, but change in a cell- and synapse-specific manner during development and …

Calcium (Ca 2+ ) influx through NMDA receptors (NMDARs) is essential for synaptogenesis,
experience-dependent synaptic remodeling and plasticity. The NMDAR-mediated rise in …

Persistent alterations in network activity trigger compensatory changes in excitation and
inhibition that restore neuronal firing rate to an optimal range. One example of such synaptic …

… C. Geoffrey Lau 1 … GluR4 delivery requires PKA-dependent phosphorylation at Ser 842 in
its C-terminal tail [80,81]. Thus a deficit in RIIβ, which is required for correct targeting of PKA to …

The NMDA-type glutamate receptor (NMDAR) is essential for synaptogenesis, synaptic
plasticity, and higher cognitive function. Emerging evidence indicates that NMDAR Ca 2+ …

Protein kinase C (PKC) enhances NMDA receptor (NMDAR)-mediated currents and
promotes NMDAR delivery to the cell surface via SNARE-dependent exocytosis. Although the …

Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in
the pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the …

The hippocampus is broadly impacted by neuromodulations. However, how neuropeptides
shape the function of the hippocampus and the related spatial learning and memory remains …

The broadly-distributed, non-topographic projections to and from the olfactory cortex may
suggest a flat, non-hierarchical organization in odor information processing. Layer 2 principal …

Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast
cancer with poor prognosis. By performing multiomic profiling, we recently uncovered super-…