Apelin is an endogenous depressor peptide for the G protein-coupled APJ receptor. Our
hypothesis is that apelin is a venodilator, and it reduces mean circulatory filling pressure (MCFP…

The venous system contains ∾70% of the blood volume. The sympathetic nervous system is
by far the most important vasopressor system in the control of venous capacitance. The …

Cardiovascular disease is the leading cause of death in people with severe mental disorders,
and rates are proportionally greater than for other diseases such as cancer. Reports of …

The venous system contains about 70% of the blood volume, and approximately 75% of the
venous volume is in the small veins and venules. Veins play an active role in the control of …

We examined if administration of an antioxidant compound protects against the development
of insulin resistance and hypertension. Male rats were assigned randomly into four groups, …

Background: The second-generation antipsychotic drug olanzapine is an effective
pharmacological treatment for psychosis. However, use of the drug is commonly associated with a …

Background The second generation antipsychotic (SGA) drugs are widely used in psychiatry
due to their clinical efficacy and low incidence of neurological side-effects. However, many …

Second generation antipsychotic drugs are routinely used as treatment for psychotic disorders.
Many of these compounds, including olanzapine, cause metabolic side-effects such as …

The venous system is supremely important in the control of cardiac output. Drugs which affect
the venous system have profound effects on haemodynamics. This review comments on …

1 Adrenomedullin is a novel vasoactive peptide which is produced in the lungs, ventricle,
kidneys, heart and adrenal medulla. Adrenomedullin shows homology to calcitonin gene‐…