Although homo-oligomerization has been reported for several G protein-coupled receptors,
this phenomenon was not studied at low concentrations of receptors. Furthermore, it is not …

SR 142948A, 2-{[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N-methylcarbamoyl)-2-isopropylphenyl)-1H-pyrazole-3-carbonyl]amino}adamantane-2-carboxylic
acid, …

β-Arrestins (βarr) are multifunctional adaptor proteins that can act as scaffolds for G protein-coupled
receptor activation of mitogen-activated protein kinases (MAPK). Here, we identify …

G-protein-coupled receptors (GPCRs) are dynamically regulated by various mechanisms
that tune their response to external stimuli. Modulation of their plasma membrane density, via …

The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic
responses after brain injection. Recent pharmacological evidence obtained with NT agonists …

Arrestins are important proteins, which regulate the function of serpentine heptahelical receptors
and contribute to multiple signaling pathways downstream of receptors. The ubiquitous …

Two G protein-coupled neurotensin (NT) receptors, termed NTR1 and NTR2, have been
identified so far. In contrast to the NTR1, which has been extensively studied, little is known …

The neurotensin receptor 1 (NTR1) subtype belongs to the family of G protein-coupled
receptors and mediates most of the known effects of the neuropeptide including modulation of …

The two neurotensin receptor subtypes known to date, NTR1 and NTR2, belong to the
family of G-protein-coupled receptors with seven putative transmembrane domains (TM). SR …

β-arrestins (β-arrs), two ubiquitous proteins involved in serpentine heptahelical receptor
regulation and signaling, form constitutive homo- and heterooligomers stabilized by inositol 1,2,3…