Acute brain injuries have been identified as a risk factor for developing Alzheimer's disease (AD).
Because glutamate plays a pivotal role in these pathologies, we studied the influence …

Peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to reduce
inflammation in various inflammatory diseases. As traumatic brain injury (TBI) caused a …

Traumatic brain injury produces nitric oxide and reactive oxygen species. Peroxynitrite, resulting
from the combination of nitric oxide and superoxide anions, triggers DNA strand breaks, …

Bradykinin promotes neuronal damage and brain edema through the activation of the B 2
receptor. The neuroprotective effect of LF 16‐0687 Ms, a B 2 receptor antagonist, has been …

The role of nitric oxide (NO) in the development of post-ischemic cerebral infarction has been
extensively examined, but fewer studies have investigated its role in other outcomes. In the …

Traumatic brain injury produces peroxynitrite, a powerful oxidant which triggers DNA strand
breaks, leading to the activation of poly(ADP-ribose)polymerase-1 (PARP-1). We previously …

Objective Patients suffering from traumatic brain injury (TBI) undergo rapid weight loss with
negative nitrogen balance and enhanced whole-body protein breakdown, with protein …

BACKGROUND: The metabolic response to head injury (HI) is characterized by a dysimmunity
which may be a risk factor of a septic state. The use of immune enhancing diets (IEDs) …

Oxidative stress has been shown to be implicated in the pathogenesis of central nervous
system injuries such as cerebral ischemia and trauma, and chronic neurodegenerative …

The potent non-peptide B 2 receptor (R) antagonist, Anatibant mesylate (Ms) (LF 16-0687
Ms), reduces brain edema and improves neurological function recovery in various focal and …