Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in
schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 …

TAR DNA binding protein 43 KD (TDP-43) is an essential gene that regulates gene transcription,
mRNA splicing and stability. In amyotrophic lateral sclerosis (ALS) and frontotemporal …

Context Neuronal dysfunction in cerebral cortex and other brain regions could contribute to
the cognitive and behavioral defects in autism. Objective To characterize epigenetic …

Electron cryotomography (cryoET), an electron cryomicroscopy (cryoEM) modality, has
changed our understanding of biological function by revealing the native molecular details of …

Three-dimensional chromosomal conformations regulate transcription by moving enhancers
and regulatory elements into spatial proximity with target genes. Here we describe activity-…

Vascular endothelial growth factor (VEGF) mediates increased vascular permeability and
endothelial mitogenesis, and may orchestrate normal glomerular permselectivity and …

Little is known about chromosomal loopings involving proximal promoter and distal enhancer
elements regulating GABAergic gene expression, including changes in schizophrenia and …

Less than 1.5% of the human genome encodes protein. However, vast portions of the human
genome are subject to transcriptional and epigenetic regulation, and many noncoding …

Mercuric chloride (HgCl 2 ) has contrasting effects on different rat strains: susceptible strains,
eg Brown Norway (BN) develop polyclonal B cell activation, multiple autoantibodies and …

Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs,
including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (…