Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice

D Bengel, DL Murphy, AM Andrews, CH Wichems… - Molecular …, 1998 - ASPET
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …

[HTML][HTML] Response to a monovalent 2009 influenza A (H1N1) vaccine

…, MH Lai, GF Hartel, CH Wichems… - … England Journal of …, 2009 - Mass Medical Soc
Background A novel 2009 influenza A (H1N1) virus is responsible for the first influenza
pandemic in 41 years. A safe and effective vaccine is needed. A randomized, observer-blind, …

Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other …

DL Murphy, AM Andrews, CH Wichems… - Journal of Clinical …, 1998 - psychiatrist.com
Knowledge about serotonergic neurotransmission has been expanding rapidly. Recent
research has delineated 15 molecularly different serotonin receptors and multiple, discrete …

Brain region‐specific alterations of 5‐HT2A and 5‐HT2C receptors in serotonin transporter knockout mice

Q Li, CH Wichems, L Ma, LD Van de Kar… - Journal of …, 2003 - Wiley Online Library
The aim of the present studies was to determine the effects of reduced or absent serotonin (5‐HT)
transporters (5‐HTTs) on 5‐HT 2A and 5‐HT 2C receptors. The density of 5‐HT 2C …

[PDF][PDF] Response after one dose of a monovalent influenza A (H1N1) 2009 vaccine—preliminary report

ME Greenberg, MH Lai, GF Hartel, CH Wichems… - N Engl J Med, 2009 - Citeseer
Background A novel influenza A (H1N1) 2009 virus is responsible for the first influenza
pandemic in 41 years. A safe and effective vaccine is urgently needed. A randomized, observer-…

Cognitive response to memantine in moderate to severe Alzheimer disease patients already receiving donepezil: an exploratory reanalysis

FA Schmitt, CH van Dyck, CH Wichems… - Alzheimer Disease & …, 2006 - journals.lww.com
Objective To investigate the cognitive effects of the N-methyl-D-aspartate receptor antagonist,
memantine, with a post-hoc exploratory reanalysis of a 24-week randomized, double-blind…

Novel 2-substituted cocaine analogs: uptake and ligand binding studies at dopamine, serotonin and norepinephrine transport sites in the rat brain.

BA Bennett, CH Wichems, CK Hollingsworth… - … of Pharmacology and …, 1995 - ASPET
A novel scheme utilizing vinylcarbenoid precursors has been developed for the synthesis of
tropane analogs of cocaine. Specificities of these compounds for dopamine (DA), serotonin (…

A systematic review of assessment and treatment of moderate to severe Alzheimer's disease

FA Schmitt, CH Wichems - Prim Care Companion J Clin Psychiatry, 2006 - psychiatrist.com
Objective: The systematic, large-scale study of therapies for moderate to severe Alzheimer’s
disease (AD) is a relatively recent advancement in the field. This review describes for the …

A single dose of unadjuvanted novel 2009 H1N1 vaccine is immunogenic and well tolerated in young and elderly adults

…, MH Lai, GF Hartel, CH Wichems… - The Journal of …, 2010 - academic.oup.com
Background. When the novel H1N1 influenza A strain appeared in April of 2009, development
of novel H1N1 vaccines became a public health priority. Methods. We conducted a phase-…

Release of serotonin induced by 3, 4-methylenedioxymethamphetamine (MDMA) and other substituted amphetamines in cultured fetal raphe neurons: further …

CH Wichems, CK Hollingsworth, BA Bennett - Brain research, 1995 - Elsevier
The substituted amphetamines 3,4-methylenedioxyamphetamine (MDMA), 3,4-methylenedioxyamphetamine
(MDA), p-chloroamphetamine (PCA) and fenfluramine (FEN) all exert their …