BACKGROUND: Using positron emission tomography (PET), we previously observed increases
in 3,4-dihydroxy-6-[ 18 F]fluoro-L-phenylalanine ( 18 F-DOPA) uptake in the striatum of …

The “aberrant salience” model proposes that psychotic symptoms first emerge when chaotic
brain dopamine transmission leads to the attribution of significance to stimuli that would …

BackgroundSubtle abnormalities in frontal white matter have been reported in bipolar
disorder.AimsTo assess whether impaired integrity of white matter tracts is associated with bipolar …

BackgroundWhite matter abnormalities have been implicated in the aetiology of major depressive
disorder; however, the relationship between the severity of symptoms and white matter …

Objective: Animal models suggest that the development of psychosis involves hyperactivity
in the hippocampus that drives increased activity in the midbrain and basal ganglia. The …

Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal
models suggest that this effect may be mediated by increased striatal dopamine …

Alterations in brain glutamate levels may be associated with psychosis risk, but the
relationship to clinical outcome in at-risk individuals is unknown. Glutamate concentration was …

Background: Neuroimaging studies in humans have implicated both dysfunction of the medial
temporal lobe (MTL) and the dopamine system in psychosis, but the relationship between …

Little is known about the neurobiological factors that determine functional outcome in people
at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical …

The integrity of brain white matter connections is central to a patient’s ability to respond to
pharmacological interventions. This study tested this hypothesis using a specific measure of …