Sex-specific transcriptional signatures in human depression

…, I Purushothaman, C Menard, J Wang, C Tan… - Nature medicine, 2017 - nature.com
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While
the incidence, symptoms and treatment of MDD all point toward major sex differences, the …

[PDF][PDF] The role of Cdk5 in neuroendocrine thyroid cancer

K Pozo, E Castro-Rivera, C Tan, F Plattner, G Schwach… - Cancer cell, 2013 - cell.com
Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from
calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 and p25 …

[PDF][PDF] Memory enhancement by targeting Cdk5 regulation of NR2B

…, TM Kistler, K Pozo, P Zhong, EY Yuen, C Tan… - Neuron, 2014 - cell.com
Many psychiatric and neurological disorders are characterized by learning and memory
deficits, for which cognitive enhancement is considered a valid treatment strategy. The N-methyl-…

[PDF][PDF] Sex-specific role for the long non-coding RNA LINC00473 in depression

…, YY van der Zee, A Ramakrishnan, J Wang, C Tan… - Neuron, 2020 - cell.com
Depression is a common disorder that affects women at twice the rate of men. Here, we report
that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts…

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration

…, J He, RA Shahror, RJ Henry, R Khan, C Tan… - Science …, 2023 - science.org
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins,
which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped …

The role of ventral striatal cAMP signaling in stress-induced behaviors

…, A Hernández, DR Benavides, TC Tassin, C Tan… - Nature …, 2015 - nature.com
The cAMP and cAMP-dependent protein kinase A (PKA) signaling cascade is a ubiquitous
pathway acting downstream of multiple neuromodulators. We found that the phosphorylation …

TDP43 mutation in familial amyotrophic lateral sclerosis

A Yokoseki, A Shiga, CF Tan, A Tagawa… - Annals of Neurology …, 2008 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Accumulating
evidence has shown that 43kDa TAR‐DNA–binding protein (TDP‐43) is the disease protein in …

[HTML][HTML] Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes

A Hernandez, C Tan, F Plattner, AF Logsdon, K Pozo… - Molecular Brain, 2018 - Springer
Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various
severity levels. Primary TBI from blast exposure is commonly characterized by internal …

TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

CF Tan, H Eguchi, A Tagawa, O Onodera… - Acta …, 2007 - Springer
Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of
ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether …

Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

X Zhu, B Zhou, R Pattni, K Gleason, C Tan… - Nature …, 2021 - nature.com
Retrotransposons can cause somatic genome variation in the human nervous system, which
is hypothesized to have relevance to brain development and neuropsychiatric disease. …