Sex-specific transcriptional signatures in human depression
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While
the incidence, symptoms and treatment of MDD all point toward major sex differences, the …
the incidence, symptoms and treatment of MDD all point toward major sex differences, the …
[PDF][PDF] The role of Cdk5 in neuroendocrine thyroid cancer
K Pozo, E Castro-Rivera, C Tan, F Plattner, G Schwach… - Cancer cell, 2013 - cell.com
Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from
calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 and p25 …
calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors p35 and p25 …
[PDF][PDF] Memory enhancement by targeting Cdk5 regulation of NR2B
…, TM Kistler, K Pozo, P Zhong, EY Yuen, C Tan… - Neuron, 2014 - cell.com
Many psychiatric and neurological disorders are characterized by learning and memory
deficits, for which cognitive enhancement is considered a valid treatment strategy. The N-methyl-…
deficits, for which cognitive enhancement is considered a valid treatment strategy. The N-methyl-…
[PDF][PDF] Sex-specific role for the long non-coding RNA LINC00473 in depression
…, YY van der Zee, A Ramakrishnan, J Wang, C Tan… - Neuron, 2020 - cell.com
Depression is a common disorder that affects women at twice the rate of men. Here, we report
that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts…
that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts…
Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration
…, J He, RA Shahror, RJ Henry, R Khan, C Tan… - Science …, 2023 - science.org
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins,
which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped …
which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped …
The role of ventral striatal cAMP signaling in stress-induced behaviors
The cAMP and cAMP-dependent protein kinase A (PKA) signaling cascade is a ubiquitous
pathway acting downstream of multiple neuromodulators. We found that the phosphorylation …
pathway acting downstream of multiple neuromodulators. We found that the phosphorylation …
TDP‐43 mutation in familial amyotrophic lateral sclerosis
A Yokoseki, A Shiga, CF Tan, A Tagawa… - Annals of Neurology …, 2008 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. Accumulating
evidence has shown that 43kDa TAR‐DNA–binding protein (TDP‐43) is the disease protein in …
evidence has shown that 43kDa TAR‐DNA–binding protein (TDP‐43) is the disease protein in …
[HTML][HTML] Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes
Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various
severity levels. Primary TBI from blast exposure is commonly characterized by internal …
severity levels. Primary TBI from blast exposure is commonly characterized by internal …
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
CF Tan, H Eguchi, A Tagawa, O Onodera… - Acta …, 2007 - Springer
Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of
ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether …
ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis (SALS). To clarify whether …
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Retrotransposons can cause somatic genome variation in the human nervous system, which
is hypothesized to have relevance to brain development and neuropsychiatric disease. …
is hypothesized to have relevance to brain development and neuropsychiatric disease. …