Neuromelanin-sensitive MRI (NM-MRI) purports to detect the content of neuromelanin (NM),
a product of dopamine metabolism that accumulates with age in dopamine neurons of the …

Most drugs of abuse lead to a general blunting of dopamine release in the chronic phase of
dependence, which contributes to poor outcome. To test whether cannabis dependence is …

Hallucinations, a cardinal feature of psychotic disorders such as schizophrenia, are known
to depend on excessive striatal dopamine. However, an underlying cognitive mechanism …

Background: To determine the clinical relevance of different definitions of symptom remission
for prediction of functional outcome in first-episode psychosis (FEP). Methods: One …

The clinical and pathophysiological correlates of locus coeruleus (LC) degeneration in
Alzheimer’s disease (AD) could be clarified using a method to index LC integrity in vivo, …

Importance Despite the well-established role of striatal dopamine in psychosis, current views
generally agree that cortical dysfunction is likely necessary for the emergence of psychotic …

This study evaluates how much agreement there is between subjective reports of adherence
to antipsychotic medication and objective or derived measures of adherence in first-…

BackgroundFew studies have examined the underlying factor structure of signs and symptoms
occurring before the first psychotic episode. Our objective was to determine whether …

Objective: Recent evidence supports the use of neuromelanin-sensitive MRI (NM-MRI) as a
novel tool to investigate dopamine function in the human brain. The authors investigated the …

Objective: To determine the validity and reliability of the Alcohol Use Disorders Identification
Test (AUDIT) and Drug Abuse Screening Test (DAST) for detecting alcohol and drug use …