The stimuli from a receptive female and/or copulation itself leads to the release of dopamine
(DA) in at least three integrative hubs. The nigrostriatal system promotes somatomotor …

Dopamine (DA) activity in the medial preoptic area (MPOA) contributes to the control of male
rat sexual behavior. We tested (1) whether extracellular DA increases during precopulatory …

10.7554/eLife.18246.001 Demyelination in MS disrupts nerve signals and contributes to
axon degeneration. While remyelination promises to restore lost function, it remains unclear …

NITRIC oxide (NO) is becoming recognized as an import ant intercellular messenger in the
brain. The present experiment used microdialysis to examine the potential role of NO in the …

Stimulant drugs such as amphetamine are readily self-administered by humans and laboratory
animals by virtue of their actions on dopamine (DA) neurons of the midbrain. Repeated …

Objective Scleroderma (systemic sclerosis [SSc]), is characterized by progressive multiorgan
fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of …

Prostaglandin D 2 (PGD 2 ) is one of a family of biologically active lipids derived from arachidonic
acid via the action of COX-1 and COX-2. PGD 2 is released from mast cells and binds …

Steroid hormones prime neural circuits for sexual behavior, in part by regulating enzymes,
receptors, or other proteins affecting neurotransmitter function. Dopamine facilitates male …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at
least six G protein-coupled receptors designated LPA 1–6 . LPA type 1 receptor (LPA 1 ) …

Dopamine (DA) is released in several brain areas, including the nucleus accumbens (NAcc),
before and during copulation in male rats. DA agonists administered into this area facilitate, …