Background Transplantation of human embryonic dopamine neurons into the brains of patients
with Parkinson's disease has proved beneficial in open clinical trials. However, whether …

Background Dopaminergic neuronal loss in Parkinson's disease leads to changes in the
circuitry of the basal ganglia, such as decreased inhibitory GABAergic input to the subthalamic …

We conducted a double-blinded phase I clinical trial to establish whether nicotinamide
adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), …

The differential diagnosis of parkinsonian disorders can be challenging, especially early in
the disease course. PET imaging with [ 18 F]-fluorodeoxyglucose (FDG) has been used to …

Background: Executive control of cognition, emotion, and behavior are disrupted in the manic
state of bipolar disorder. Whereas frontal systems are implicated in such dysfunction, the …

To examine the variations in regional cerebral blood flow during execution and learning of
reaching movements, we employed a family of kinematically and dynamically controlled …

Parkinson's disease (PD) is associated with abnormal activity in spatially distributed neural
systems mediating the motor and cognitive manifestations of this disorder. Metabolic PET …

Network analysis of functional brain imaging data is an innovative approach to study circuit
abnormalities in neurodegenerative diseases. In Parkinson's disease, spatial covariance …

The motor manifestations of Parkinson's disease (PD) have been linked to an abnormal spatial
covariance pattern involving basal ganglia thalamocortical pathways. By contrast, little is …

It has been proposed that deep brain stimulation (DBS) of the subthalamic nucleus (STN
DBS) and dopaminergic therapy ameliorate the symptoms of Parkinson’s disease through …