Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and γ-secretase
to release amyloid peptides (Aβ40 and 42) that aggregate to form senile plaques in the …

Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …

Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease
Aβ peptides 1, 2, 3. We report that secretion of Aβ peptides (Aβ1–40/42 and Aβ11–40/42) is …

The scrapie (PrPsC) and cellular (PrPc) prion proteins are encoded by the same gene, and
their different properties am thought to arise from posttranslational modifications. We have …

Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2),
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations
in two related genesPS1 and PS2, located on chromosome 14 and 1, respectively. Using …

Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion
of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the …

To understand gene expression changes mediated by a polyglutamine repeat expansion in
the human huntingtin protein, we used oligonucleotide DNA arrays to profile ~6000 striatal …

The introduction of two transgenes into one animal is increasingly common as transgenic
experiments become more sophisticated. In this study we examine two strategies for creating …