The striatum, which is the major component of the basal ganglia in the brain, is regulated in
part by dopaminergic input from the substantia nigra. Severe movement disorders result from …

The application of modem molecular biological methods has had an increasing and dramatic
impact upon the discipline of molecular neuropharmacology. This is particularly true for the …

Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

The authors examined the affinities of 36 typical and atypical antipsychotic agents for the
cloned rat 5-hydroxytryptamine-6 (5-HT6) and rat 5-hydroxytryptamine-7 (5-HT7) receptors in …

We have used the polymerase chain reaction technique to selectively amplify a guanine
nucleotide-binding protein-coupled receptor cDNA sequence from rat striatal mRNA that …

DOPAMINE receptors belong to a large class of neurotransmitter and hormone receptors
that are linked to their signal transduction pathways through guanine nucleotide binding …

In order to clone the D1 dopamine receptor linked to adenylyl cyclase activation, the polymerase
chain reaction was used with highly degenerate primers to selectively amplify a cDNA …

OPC-14597 {aripiprazole; 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone}
is a novel candidate antipsychotic that has high affinity for striatal …

While most effects of dopamine in the brain are mediated by the D1 and D2 receptor
subtypes, other members of this G protein-coupled receptor family have potentially important …

Desensitization, the tendency of biological responses to wane over time despite the
continuous presence of a stimulus of constant intensity, is observed in organisms as diverse as …