Previous studies demonstrated that antidepressant treatment increases the expression of
brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was …

Background Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s
disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is …

Objective To compare initial treatment with pramipexole vs levodopa in early Parkinson
disease, followed by levodopa supplementation, with respect to the development of …

Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating
processes related to mood and motivation. This review presents findings from the basic …

Reports of beneficial effects of exercise on psychological health in humans are increasingly
supported by basic research studies. Exercise is hypothesized to regulate antidepressant-…

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is upregulated in the
hippocampus by antidepressant treatments, and centrally administered BDNF can produce …

Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has
been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine …

Northern blot analysis was utilized to distinguish between catalytic and truncated TrkB mRNA
on the basis of transcript size. Repeated (10 days), but not acute, immobilization stress …

Exercise has many health benefits, including antidepressant actions in depressed human
subjects, but the mechanisms underlying these effects have not been elucidated. We used a …

Chronic morphine administration (via subcutaneous pellet) decreases the size of dopamine
neurons in the ventral tegmental area (VTA), a key reward region in the brain, yet the …