Understanding the physiopathology of affective disorders and their treatment relies on the
availability of experimental models that accurately mimic aspects of the disease. Here we …

Although hippocampal neurogenesis has been described in many adult mammals, the functional
impact of this process on physiology and behavior remains unclear. In the present study…

Chronic treatments with selective serotonin reuptake inhibitors (SSRIs) have been shown to
increase hippocampal neurogenesis. However, it is not known whether SSRIs impact the …

Nicotinic acetylcholine receptors (nAChRs) expressed by dopaminergic (DA) neurons have
long been considered as potential therapeutic targets for the treatment of several …

Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

Background Stress exposure is one of the greatest risk factors for psychiatric illnesses like
major depressive disorder and posttraumatic stress disorder. However, not all individuals …

Identifying the factors contributing to the etiology of anxiety and depression is critical for the
development of more efficacious therapies. Serotonin (5-HT) is intimately linked to both …

Serotonin 1A receptor knockout (5-HT1AR KO) mice exhibit increased behavioral inhibition
in conflict tests. To gain further insight into their anxiety-related phenotype, we subjected …

Selective serotonin reuptake inhibitors (SSRIs) display a delayed onset of action of several
weeks. Past work in naive rats showed that 5-HT 4 receptor agonists had rapid effects on …

Agomelatine (S20098) is a novel antidepressant drug with melatonergic agonist and 5-HT
2C receptor antagonist properties, displaying antidepressant/anxiolytic-like properties in …