OBJECTIVE: The understanding of suicidal behavior is incomplete. The stress-diathesis model
suggests that a deficit in serotonergic projections to the orbitofrontal cortex is involved in …

The basis of suicidal behavior (SB) is complex and multifactorial. Numerous risk factors have
been identified. Epidemiological genetics studies (family studies, twin studies, adoption …

BACKGROUND: In the first year following a suicide attempt, patients are at high risk for
reattempt and for completed suicide. We aim to determine the predictive value of two serotonin-…

BACKGROUND: Decision-making has been found to be altered in suicide attempters and
may represent a neuropsychological trait of vulnerability to suicidal behaviour. Environmental …

Genetic factors have been associated with the vulnerability to suicidal behavior. We previously
reported decision‐making impairment in suicide attempters and hypothesized that these …

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GAELLE LEROUX,~ ANDREE MADEC,-/’ MICHEL SELIN,~ JEAN-CLAUDE CHAMPIAT …

Objective Compelling evidence suggests that serotonin system dysfunction is associated
with certain behavioral disorders, including suicidal behavior and impulsive aggression. A …

Background: To determine whether the tryptophan hydroxylase gene (ie, the gene that codes
for the rate-limiting enzyme in the metabolic pathway of serotonin) may be a susceptibility …

There is compelling evidence that suicidal behavior is associated with the dysfunction of the
serotonin system. A functional polymorphism in the promoter region of the serotonin …

Background: The inconsistency of the results obtained in biological studies of suicidal behavior
may be due to the use of broad categories lacking validity. In previous genetic studies, in …