Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

KP Lesch, D Bengel, A Heils, SZ Sabol, BD Greenberg… - Science, 1996 - science.org
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated
in anxiety in humans and animal models and is the site of action of widely used uptake-…

Allelic variation of human serotonin transporter gene expression

…, S Petri, G Stöber, P Riederer, D Bengel… - Journal of …, 1996 - Wiley Online Library
Mood, emotion, cognition, and motor functions as well as circadian and neuroendocrine
rhythms, including food intake, sleep, and reproductive activity, are modulated by the midbrain …

Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice

D Bengel, DL Murphy, AM Andrews, CH Wichems… - Molecular …, 1998 - ASPET
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …

Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets

…, TJ Tolliver, SJ Huang, Q Li, D Bengel… - American journal of …, 1999 - Wiley Online Library
The human serotonin transporter (5‐HTT), encoded by a single gene on chromosome 17q11.2,
is expressed in brain and blood cells. 5‐HTT is implicated in mood and anxiety regulation…

Role of the serotonin transporter promoter polymorphism in anxiety-related traits

…, J Lappalainen, JC Long, D Bengel… - Archives of General …, 1998 - jamanetwork.com
Background The heritability of interindividual variation in anxiety and other aspects of
personality establishes that variants of genes influence these traits. A functional polymorphism in …

Cellular localization and expression of the serotonin transporter in mouse brain

D Bengel, O Jöhren, AM Andrews, A Heils, R Mößner… - Brain research, 1997 - Elsevier
The high-affinity serotonin (5-HT) transporter (5-HTT) plays an important role in the removal
of extracellular serotonin, thereby modulating and terminating the action of this …

Gene structure and 5′-flanking regulatory region of the murine serotonin transporter

D Bengel, A Heils, S Petri, M Seemann, K Glatz… - Molecular brain …, 1997 - Elsevier
By modulating the magnitude and duration of postsynaptic responses, carrier-facilitated
serotonin (5-HT) transport into and release from the presynaptic neuron is central to the fine …

[HTML][HTML] A biochemical marker panel in MRI-proven hyperacute ischemic stroke-a prospective study

C Knauer, K Knauer, S Müller, AC Ludolph, D Bengel… - BMC neurology, 2012 - Springer
Background Computer tomography (CT) is still the fastest and most robust technique to rule
out ICH in acute stroke. However CT-sensitivity for detection of ischemic stroke in the …

Serotonin transporter (5‐HTT) gene and bipolar affective disorder

…, G Turner, JA Badner, D Bengel… - American journal of …, 1998 - Wiley Online Library
Interactions with antidepressants, as well as other biochemical evidence, implicate the
serotonin transporter 5‐HTT in the etiology of affective disorders. However, genetic studies have …

Long-term outcome in transient global amnesia patients with and without focal hyperintensities in the CA1 region of the hippocampus

I Uttner, S Prexl, W Freund, A Unrath, D Bengel… - European …, 2012 - karger.com
Focal hippocampal diffusion-weighted imaging (DWI) lesion patterns are detected in transient
global amnesia (TGA) patients in different frequency. It has been speculated that acute …