Disruptions in circadian rhythms have been described in mood disorders (MD), but the
involvement of genetic variation in genes pertaining to the molecular circadian machinery in the …

Deep brain stimulation (DBS) is currently tested as an experimental therapy for patients with
treatment-resistant depression (TRD). Here we report on the short- and long-term (1 yr) …

OBJECTIVE: The aim of this study was to determine the efficacy and safety of dialectical
behavior therapy plus olanzapine compared with dialectical behavior therapy plus placebo in …

A number of theorists have proposed that the Behavioural Inhibition System (BIS) and the
Behavioural Activation System (BAS) could be abnormal in subjects with depression. Subjects …

Background Pindolol has been reported to hasten the antidepressant action of selective
serotonin reuptake inhibitors in open-label and placebo-controlled trials. Pilot studies also …

BACKGROUND: Few studies have addressed the implication of the duration of untreated
illness (DUI) on the clinical outcome of mood disorders. Although not focusing on DUI, previous …

Background: To date, antidepressant drugs show limited efficacy, leaving a large number of
patients experiencing severe and persistent symptoms of major depression. Previous open-…

Structural and neuropathological alterations in the ventromedial prefrontal cortex (vmPFC)
described in depression (MDD) might become even more pronounced over the course of …

BackgroundFindings of brain structural changes in major depressive disorder are still
inconsistent, partly because some crucial clinical variables have not been taken into account.…

Background Up to 30% of patients with schizophrenia are resistant to antipsychotic drug
treatment, with 60% of such cases also failing to respond to clozapine. Deep brain stimulation (…