Great emphasis is being placed on identification of neurotransmitter systems involved in the
symptomatic manifestations of neurological and psychiatric disorders. In the case of …

▪ Abstract The most common cause of dementia occurring in mid- to late-life is Alzheimer's
disease (AD). Some cases of AD, particularly those of early onset, are familial and inherited as …

▪ Abstract Recent advances in a variety of areas of research, particularly in genetics and in
transgenic (Tg)/gene targeting approaches, have had a substantial impact on our …

Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal
forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. …

The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When
compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …

Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease
Aβ peptides 1, 2, 3. We report that secretion of Aβ peptides (Aβ1–40/42 and Aβ11–40/42) is …

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations
in two related genesPS1 and PS2, located on chromosome 14 and 1, respectively. Using …

Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2),
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …