Obsessive-compulsive disorder (OCD) and autism spectrum disorders (ASD) are serious and
debilitating psychiatric conditions and each constitutes a significant public health concern, …

A novel method for the study of repetitive mild traumatic brain injury (rmTBI) that models the
most common form of head injury in humans is presented. Existing animal models of TBI …

Methamphetamine intoxication causes long-lasting damage to dopamine nerve endings in
the striatum. The mechanisms underlying this neurotoxicity are not known but oxidative stress …

Quinone derivatives of DOPA, dopamine, and N‐acetyldopamine inactivate tyrosine
hydroxylase, the initial and rate‐limiting enzyme in the biosynthesis of the catecholamine …

Chronic cocaine abuse induces long‐term neural adaptations as a consequence of alterations
in gene expression. This study was undertaken to identify those transcripts differentially …

Neurotoxic amphetamines cause damage to monoamine nerve terminals of the striatum by
unknown mechanisms. Microglial activation contributes to the neuronal damage that …

Though the most recognizable symptoms of Parkinson's disease (PD) are motor-related,
many patients also suffer from debilitating affective symptoms that deleteriously influence …

Autism is a complex neurodevelopmental disorder characterized by impaired reciprocal
social interaction, communication deficits and repetitive behaviors. A very large number of …

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of the neurotransmitter
serotonin. Once thought to be a single-gene product, TPH is now known to exist in two …

… Address correspondence and reprint requests to Donald M. Kuhn, John D. Dingell VA Medical
Center, R&D Service (11R), 4646 John R, Detroit, MI 48201, USA. E-mail: [email protected…