Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum …
DF MacFabe, DP Cain, K Rodriguez-Capote… - Behavioural brain …, 2007 - Elsevier
Clinical observations suggest that certain gut and dietary factors may transiently worsen
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …
symptoms in autism spectrum disorders (ASD), epilepsy and some inheritable metabolic …
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats …
…, NE Cain, F Boon, KP Ossenkopp, DP Cain - Behavioural brain …, 2011 - Elsevier
Recent evidence suggests that a variety of environmental factors, including dietary and
gastrointestinal agents, may contribute to autism spectrum disorders (ASD). Here we …
gastrointestinal agents, may contribute to autism spectrum disorders (ASD). Here we …
Spatial learning without NMDA receptor-dependent long-term potentiation
D Saucier, DP Cain - Nature, 1995 - nature.com
HIPPOCAMPAL lesions impair spatial learning in the watermaze 1 . Drugs that antagonize N-methyl-D-aspartate
(NMDA)-receptor activity, which is required for long-term potentiation (…
(NMDA)-receptor activity, which is required for long-term potentiation (…
Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of …
Environmental, dietary, and gastrointestinal factors may contribute to autism spectrum
disorders (ASD). Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of …
disorders (ASD). Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of …
Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: further …
…, R Taylor, F Boon, KP Ossenkopp, DP Cain - Behavioural brain …, 2009 - Elsevier
Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric
bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral …
bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral …
Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments
…, DF MacFabe, KA Foley, R Taylor, DP Cain - Behavioural brain …, 2012 - Elsevier
Sub-concussive brain injuries may result in neurophysiological changes, cumulative effects,
and neurodegeneration. The current study investigated the effects of a mild lateral fluid …
and neurodegeneration. The current study investigated the effects of a mild lateral fluid …
A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long–Evans rat: Support for an animal model of concussion
…, DF MacFabe, KA Foley, R Taylor, DP Cain - Behavioural brain …, 2011 - Elsevier
Brain concussion is a serious public health concern and is associated with short-term cognitive
impairments and behavioral disturbances that typically occur in the absence of significant …
impairments and behavioral disturbances that typically occur in the absence of significant …
Long-term potentiation and kindling: how similar are the mechanisms?
DP Cain - Trends in neurosciences, 1989 - Elsevier
Long-term potentiation (LTP) 1 and kindling 2 are strikingly similar in many respects. Both
are believed to model CNS plasticity, both are induced by the localized application of brief, …
are believed to model CNS plasticity, both are induced by the localized application of brief, …
[PDF][PDF] A novel rodent model of autism: intraventricular infusions of propionic acid increase locomotor activity and induce neuroinflammation and oxidative stress in …
…, AR Taylor, F Boon, DP Cain… - Am J Biochem …, 2008 - researchgate.net
Innate neuroinflammatory changes, increased oxidative stress and disorders of glutathione
metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD). …
metabolism may be involved in the pathophysiology of autism spectrum disorders (ASD). …
The role of the olfactory bulb in limbic mechanisms.
DP Cain - Psychological Bulletin, 1974 - psycnet.apa.org
Reviews recent data obtained after peripheral olfactory system damage which, when
compared with bulbectomy data, suggest that the olfactory bulb has certain general modulatory …
compared with bulbectomy data, suggest that the olfactory bulb has certain general modulatory …