THE appropriate and rational use of drugs by the elderly is a matter of growing medical and
social concern. Life expectancy in the Western world currently stands at 69 years for men …

Most drugs are carried from their sites of absorption to their sites of action and elimination by
the circulating blood. Some drugs are simply dissolved in serum water, but many others are …

Nicotine is the primary addictive compound in tobacco smoke. In this review we summarize
nicotine dependence and the genetics of smoking in brief before focusing on cytochrome …

The estimation of the probability that a drug caused an adverse clinical event is usually based
on clinical judgment. Lack of a method for establishing causality generates large between‐…

A shortened 10‐item scale for clinical quantitation of the severity of the alcohol withdrawal
syndrome has been developed. This scale offers an increase in efficiency while at the same …

Nicotine is the primary compound in tobacco that establishes and maintains tobacco dependence
1 . Most of this nicotine is metabolized to cotinine by the genetically variable enzyme …

We conducted a double-blind, placebo-controlled trial in which 40 patients who had undergone
long-term therapy with benzodiazepines were switched to placebo or to diazepam in a …

Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our
objective was to investigate allele frequencies among five ethnic groups and to investigate …

In humans, 80% of nicotine is metabolized to the inactive metabolite cotinine by the enzyme
CYP2A6, which can also activate tobacco smoke procarcinogens (eg, 4-(methylnitrosamino)-…

The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means
of predicting potential drug-drug interactions, have not yet been investigated. The objective …