The cortico-limbic system is critically involved in emotional responses and resulting adaptive
behaviors. Within this circuit, complementary regions are believed to be involved in either …

HLA-G is a nonclassical class I antigen mainly expressed at the maternofetal interface during
pregnancy where it is thought to downmodulate maternal immune response against the …

The 5′ and 3′ splice sites within an intron can, in principle, be joined to those within any
other intron during pre-mRNA splicing. However, exons are joined in a strict 5′ to 3′ linear …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Mutations that affect the splicing of pre-mRNA are a major cause of human disease. Familial
dysautonomia (FD) is a recessive neurodegenerative disease caused by a T to C transition …

It remains unclear why many patients with depression do not respond to antidepressant
treatment. In three cohorts of individuals with depression and treated with serotonin-…

Previous studies indicate that the nonclassical class I HLA‐G antigen, whose physiologic
expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung …

Major depressive disorder (MDD) is a complex and debilitating illness whose etiology remains
unclear. Small RNA molecules, such as micro RNAs (miRNAs) have been implicated in …

Major depressive disorder (MDD) is a highly prevalent mental illness whose therapy
management remains uncertain, with more than 20% of patients who do not achieve response to …

Depression, a devastating psychiatric disorder, is a leading cause of disability worldwide.
Current antidepressants address specific symptoms of the disease, but there is vast room for …