Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six proteins
are 36–48 percent identical and seem to have two transmembrane segments with a large …

Alcoholism is a complex behavioral disorder characterized by excessive consumption of
ethanol, a narrowing of the behavioral repertoire toward excessive consumption, the …

The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central
nervous system in ways that mimic stress and result in decreases in exploration, increases in …

Release of the neurotransmitter dopamine in the mesolimbic system of the brain mediates the
reinforcing properties of several drugs of abuse, including nicotine 1 . Here we investigate …

We describe a stereotaxic rat brain MRI template set with a co-registered digital anatomical
atlas and illustrate its application to the analysis of a pharmacological MRI (phMRI) study of …

Background Depression is associated with interpersonal difficulties related to abnormalities
in affective facial processing. Objectives To map brain systems activated by sad facial affect …

BACKGROUND: It would be therapeutically useful to predict clinical response to antidepressant
drugs. We evaluated structural magnetic resonance imaging (MRI) and functional MRI (…

Despite significant research efforts aimed at understanding the neurobiological underpinnings
of psychiatric disorders, the diagnosis and the evaluation of treatment of these disorders …

NICOTINE affects many aspects of behaviour including learning and memory 1,2 through its
interaction with neuronal nicotinic acetylcholine receptors (nAChR). Functional nAChRs are …

The function of neuropeptide Y, one of the most abundant peptide transmitters of the mammalian
brain, remains unclear because of a lack of specific receptor antagonists. An antisense …