Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF …

Schizophrenia is a chronic and disabling brain disease characterized by psychotic
episodes with unknown etiology. It is suggested that neuroinflammation plays a role in the …

Increased glucose metabolism of inflammatory tissues is the main source of false-positive
18 F-FDG PET findings in oncology. It has been suggested that radiolabeled nucleosides …

Oestrogen receptors are overexpressed in around 70% of all breast cancers, and are a target
for endocrine therapy. These receptors can be visualised on PET with use of 16α-[ 18 F]-…

FDG-PET, combined with CT, is nowadays getting more and more relevant for the diagnosis
of several infectious and inflammatory diseases and particularly for therapy monitoring. Thus…

Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …

Background: The “monocyte-T-cell theory of mood disorders” regards neuroinflammation, ie
marked activation of microglia, as a driving force in bipolar disorder. Microglia activation can …

16α- 18 F-fluoro-17β-estradiol ( 18 F-FES) is an estrogen receptor (ER)–specific PET tracer
with various potential interesting applications. The precise contribution of this technique in …

Background Activation of microglia cells plays an important role in neurological diseases.
Positron emission tomography (PET) with [ 11 C]-(R)-PK11195 has already been used to …

Despite the development of new therapeutic strategies, cancer remains incurable in most
patients with advanced disease. A recent potential improvement in therapeutic strategies is the …