Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
MT Ray, CS Weickert, E Wyatt, MJ Webster - Journal of Psychiatry and …, 2011 - jpn.ca
Background: Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor (trkB-TK+)
and glutamic acid decarboxylase (GAD 67 ) mRNA levels have previously been found to be …
and glutamic acid decarboxylase (GAD 67 ) mRNA levels have previously been found to be …
[HTML][HTML] Immunosuppressive IDO in cancer: mechanisms of action, animal models, and targeting strategies
Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes
the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the …
the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the …
Decreased glutamic acid decarboxylase67 mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
M Thompson, CS Weickert, E Wyatt… - Journal of psychiatric …, 2009 - Elsevier
Reduced levels of glutamic acid decarboxylase 67 (GAD 67 ), an essential enzyme for
GABA synthesis, is one of the most consistent gene expression changes found in the frontal …
GABA synthesis, is one of the most consistent gene expression changes found in the frontal …
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
R Wu, E Wyatt, K Chawla, M Tran… - EMBO molecular …, 2012 - embopress.org
Hexokinase‐II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer
membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid …
membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid …
Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury
R Wu, KM Smeele, E Wyatt, Y Ichikawa… - Circulation …, 2011 - Am Heart Assoc
Rationale: Cardiomyocytes switch substrate utilization from fatty acid to glucose under
ischemic conditions; however, it is unknown how perturbations in glycolytic enzymes affect …
ischemic conditions; however, it is unknown how perturbations in glycolytic enzymes affect …
[HTML][HTML] Regulation and cytoprotective role of hexokinase III
E Wyatt, R Wu, W Rabeh, HW Park, M Ghanefar… - PloS one, 2010 - journals.plos.org
Background Hexokinases (HKs) catalyze the first step in glucose metabolism. Of the three
mammalian 100-kDa HK isoforms, HKI and II can bind to mitochondria and protect against cell …
mammalian 100-kDa HK isoforms, HKI and II can bind to mitochondria and protect against cell …
A role for alternative splicing in circadian control of exocytosis and glucose homeostasis
…, Y Kobayashi, MV Newman, EJ Wyatt… - Genes & …, 2020 - genesdev.cshlp.org
The circadian clock is encoded by a negative transcriptional feedback loop that coordinates
physiology and behavior through molecular programs that remain incompletely understood. …
physiology and behavior through molecular programs that remain incompletely understood. …
[HTML][HTML] Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease
…, P Page, LM Dellefave-Castillo, EM McNally, EJ Wyatt - Skeletal Muscle, 2016 - Springer
Background Cellular models of muscle disease are taking on increasing importance with
the large number of genes and mutations implicated in causing myopathies and the …
the large number of genes and mutations implicated in causing myopathies and the …
[HTML][HTML] Distinct pathological signatures in human cellular models of myotonic dystrophy subtypes
…, AH Vo, AM Gacita, EJ Schuster, EJ Wyatt… - JCI insight, 2019 - ncbi.nlm.nih.gov
Myotonic dystrophy (DM) is the most common autosomal dominant muscular dystrophy and
encompasses both skeletal muscle and cardiac complications. DM is nucleotide repeat …
encompasses both skeletal muscle and cardiac complications. DM is nucleotide repeat …
Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection
SARS-CoV-2 is spread through exhaled breath of infected individuals. A fundamental
question in understanding transmission of SARS-CoV-2 is how much virus an individual is …
question in understanding transmission of SARS-CoV-2 is how much virus an individual is …
