Amphetamine is a psychostimulant commonly used to treat several disorders, including
attention deficit, narcolepsy, and obesity. Plasmalemmal and vesicular monoamine transporters, …

Methamphetamine (METH) is a powerful stimulant of abuse with potent addictive and
neurotoxic properties. More than 2.5 decades ago, METH-induced damage to dopaminergic …

Regulator of G-protein–signaling (RGS) proteins play a key role in the regulation of G-protein–coupled
receptor (GPCR) signaling. The characteristic hallmark of RGS proteins is a …

It is well accepted that methylphenidate (MPD) inhibits dopamine (DA) transporter function.
In addition to this effect, this study demonstrates that MPD increases vesicular [ 3 H]DA …

Monoamine transporters such as the dopamine (DA) transporter (DAT) and the vesicular
monoamine transporter-2 (VMAT-2) are critical regulators of DA disposition within the brain. …

High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone
or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter …

It has been hypothesized that high-dose methamphetamine treatment rapidly redistributes
cytoplasmic dopamine within nerve terminals, leading to intraneuronal reactive oxygen …

This laboratory has demonstrated that a single methamphetamine (METH) injection rapidly
and reversibly decreases the activity of the dopamine transporter (DAT), as assessed ex vivo …

High-dose administration of cocaine or methamphetamine to rats acutely (≤24 h) alters
vesicular dopamine transport. This study elucidates the nature of these changes. Results reveal …

Multiple high-dose administrations of methamphetamine (METH) both rapidly (within hours)
decrease plasmalemmal dopamine (DA) uptake and cause long-term deficits in DA …