In response to stress, the brain activates several neuropeptide-secreting systems. This eventually
leads to the release of adrenal corticosteroid hormones, which subsequently feed back …

… (CP) from families without history for psychiatric morbidity were found to be significantly (F
2,129 = 16.36, p < .001) different. (Adapted from Holsboer et al. 1995 and additional data) …

Neuroendocrine studies strongly suggest that dysregulation of the hypothalamic–pituitary–adrenocortical
(HPA) system plays a causal role in the development and course of depression…

Adverse early life events can induce long-lasting changes in physiology and behavior. We
found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone …

Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …

… e, Section of * the adrenal gland showing intense labelling of the adrenal medulla (Med)
compared with the adrenal cortex (Cx), f, Molecular forms of PACAP receptor mRNA detected …

… open field under basal conditions (F 2,29 =4.9, P=0.015). Alcohol withdrawal-reduced
exploratory activity was observed in all groups (F 1,58 =53.7, P<0.0001; means ±sem, * , P<0.01). …

The stress hormone–regulating hypothalamic-pituitary-adrenal (HPA) axis has been
implicated in the causality 1 as well as the treatment of depression 2 . To investigate a possible …

… von Bardeleben U, Holsboer F 1989 Cortisol response to a combined dexamethasone-human
corticotropin-releasing hormone (CRH) challenge in patients with depression. J …

… The increase of the standard deviation with age was estimated using male and female data
together in the model standard deviation = f + g * age. The model has an r 2 of 0.59. A variant …