Acetylcholinesterase(AChE) inhibitors from several chemical classes have been tested for
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …

The synthesis of a series of 3-(l-substituted-4-piperidinyl)-l, 2-benzisoxazoles is described.
The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and …

The synthesis of a series of 9-amino-l, 2, 3, 4-tetrahydroacridin-l-ols is reported. These
compounds are related to l, 2, 3, 4-tetrahydro-9-acridinamine (THA, tacrine). They inhibit …

A series of novel N-(4-pyridinyl)-1H-indol-1-amines and other heteroaryl analogs was
synthesized and evaluated in tests to determine potential utility for the treatment of Alzheimer's …

A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated
as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen …

cholinergic releasing agents, 5 and cholinesterase inhibitors6 have shown activity in AD
patients in experimentalsitu-ations. Furthermore, a recent clinical report on the efficacy of the …

A series of 5-amino-5, 6, 7, 8-tetrahydroquinoIinones was designed and synthesized as
acetylcholinesterase inhibitors. The compounds are related to hyperzine A, a naturally occurring …

Levels of morphine in brain and other biological materials were measured fluorometrically,
and relationships were drawn to tail-flick activity and to tolerance development in rats treated …

A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds
were evaluated for cholinomimetic-like properties in vitro (inhibition of [ 3 H]quinuclidinyl …

Ten 9-amino-1,2,3,4-tetrahydroacridinediols were prepared as potential mono-hydroxy
metabolites of velnacrine. They were tested for acute toxicity as well as for their ability to inhibit …