Objective: Previous studies have suggested that oxidative stress may play a role in the
pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and …

Malathion is a pesticide with high potential for human exposure. However, it is possible that
during the malathion metabolism, there is generation of reactive oxygen species (ROS) and …

Methylphenidate (MPH) is frequently prescribed for the treatment of attention deficit/hyperactivity
disorder. Psychostimulants can cause long-lasting neurochemical and behavioral …

Typical and atypical antipsychotic drugs have been shown to have different clinical and
behavioral profiles. Haloperidol (HAL) is a typical neuroleptic that acts primarily as a D 2 …

Studies have demonstrated that oxidative stress is associated with amphetamine-induced
neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after …

The mechanisms responsible to the development of brain dysfunction during sepsis are not
well understood. The objective of this study is to evaluate mitochondrial respiratory chain …

Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissuein
vivo, including the central nervous system (CNS). The aim of this study was to examine …

Methylphenidate (MPH) is psychostimulants used to treat Attention-Deficit/Hyperactivity
Disorder and can lead to a long-lasting neurochemical and behavioral adaptations in …

Studies have consistently reported the participation of free radicals in Bipolar Disorder.
Administration of d-amphetamine (d-AMPH) is a relevant animal model of mania and it increases …

The pathogenesis of sepsis is characterized by an overwhelming systemic inflammatory
response that can lead to multiple organ failure. Considering that we have recently …