Background: Approximately 40% to 70% of neuroleptic-resistant schizophrenic patients are
nonresponders to clozapine. Several clozapine augmentation strategies have come into …

Introduction: Broadly defined behavioral addiction is a conceptual framework including
behaviors characterized by loss of control and continuation despite significant negative …

Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical
use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we aimed at …

Schizophrenia likely results from poorly understood genetic and environmental factors. We
studied the gene encoding the synaptic protein SHANK3 in 285 controls and 185 …

INTRODUCTION: Preliminary studies have suggested that balneotherapy (BT) is an effective
and well-tolerated treatment for generalized anxiety disorder (GAD) and psychotropic …

<p id="p001">Although autosomal forms of nonsyndromic mental retardation account for the
majority of cases of mental retardation, the genes that are involved remain largely unknown. …

Attempted suicide is a strong risk factor for subsequent suicidal behavior. In recent years, a
particular interest has been given to follow-up interventions as a potential effective strategy in …

Although the benefits of clozapine have been well demonstrated in resistant schizophrenia,
the frequency of adverse events is of particular concern: up to 76% of patients to whom …

Background Histone deacetylases (HDACs) are key enzymes of histone acetylation, and
abnormalities in histone modifications and in the level of HDAC proteins have been reported in …

The long lapse between the presumptive origin of schizophrenia (SCZ) during early
development and its diagnosis in late adolescence has hindered the study of crucial …