Background Background Activated microglia have a key role in the brain's immune response
to neuronal degeneration. The transition of microglia from the normal resting state to the …

Objective: Patient outcome after traumatic brain injury (TBI) is highly variable. The underlying
pathophysiology of this is poorly understood, but inflammation is potentially an important …

Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder associated with akinesia,
tremor and rigidity. While the characteristic Lewy body pathology targets pigmented and …

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised
amyloid load. Here we studied in vivo the distributions of amyloid load and microglial …

The functions of the resting state networks (RSNs) revealed by functional MRI remain
unclear, but it has seemed possible that networks emerge in parallel with the development of …

Networks, as efficient representations of complex systems, have appealed to scientists for a
long time and now permeate many areas of science, including neuroimaging (Bullmore and …

It is widely held that the frontal cortex plays a critical part in certain aspects of spatial and
non‐spatial working memory. One unresolved issue is whether there are functionally distinct …

Objective: The purpose of this study was to determine whether microglial activity, measured
using translocator-protein positron emission tomography (PET) imaging, is increased in …

PET with [ 11 C]-(R)-PK11195 is currently the modality of choice for the in vivo imaging of
microglial activation in the human brain. In this work we devised a supervised clustering …

Objective: While there is robust evidence of elevated dopamine synthesis capacity once a
psychotic disorder has developed, little is known about whether it is altered prior to the first …