Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought
to play an important role in neurodegenerative disorders, including Alzheimer's and …

Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been
closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has …

Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway (KP) of
tryptophan degradation, has been suggested to play a major role in physiological and …

Background: Neuroinflammatory processes are increasingly believed to participate in the
pathophysiology of a number of major psychiatric diseases, including depression. Immune …

Importance Several lines of evidence have linked the endogenous neuromodulator
kynurenic acid (KYNA) to schizophrenia. The pathophysiology of schizophrenia is commonly …

A major trend in biomedical engineering is the development of reliable, self-contained point-of-care
(POC) devices for diagnostics and in-field assays. The new generation of such …

The kynurenine pathway (KP) of tryptophan degradation contains several neuroactive
metabolites that may influence brain function in health and disease. Mounting focus has been …

Background In mammals, the majority of the essential amino acid tryptophan is degraded
via the kynurenine pathway (KP). Several KP metabolites play distinct physiological roles, …

Cognitive impairments predict poor functional outcomes in people with schizophrenia. These
impairments may be causally related to increased levels of kynurenic acid (KYNA), a major …

Maternal immune activation (MIA) with the viral mimic poly I:C provides an established rodent
model for studying schizophrenia (SZ) and other human neurodevelopmental disorders. …