After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent
advances in our understanding of the neurobiology of psychedelics, such as lysergic acid …

Rationale Serotonin (5-Hydroxytryptamine, 5-HT) receptors play an important role in
perception, affect regulation and attention. Pharmacological challenge with the 5-HT 2A agonist …

Increasing evidence from neuroimaging and behavioral studies suggests that functional
disturbances within cortico-striato-thalamic pathways are critical to psychotic symptom formation …

Renewed interest in the use of psychedelics in the treatment of psychiatric disorders warrants
a better understanding of the neurobiological mechanisms underlying the effects of these …

The history of serotonin research is closely related to the study of hallucinogenic drugs that
function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states …

Background After no research in humans for >40 years, there is renewed interest in using
lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no …

Visual illusions and hallucinations are hallmarks of serotonergic hallucinogen-induced
altered states of consciousness. Although the serotonergic hallucinogen psilocybin activates …

Psychedelics exert unique effects on human consciousness. The thalamic filter model suggests
that core effects of psychedelics may result from gating deficits, based on a disintegration …

PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in
humans that resembles first episodes of schizophrenia. In healthy human volunteers, the …

Background In patients with schizophrenia, deficient generation of mismatch negativity (MMN)—an
event-related potential (ERP) indexing auditory sensory ("echoic") memory—and a …