Acidic amino acids are putative excitatory synaptic transmitters 1,2 , the ionic mechanism of
which is not well understood. Recent studies with selective agonists and antagonists suggest …

Excitatory amino acids act via receptor subtypes in the mammalian central nervous system (CNS)
1–3 . The receptor selectively activated by N-methyl-D-aspartic acid (NMDA) has been …

Physiologists have been aware of the excitatory action of L-glutamate on vertebrate CNS
neurons for over 30 years, yet characterization of the mechanism of action of excitatory amino …

NMDA (N-methyl-D-aspartate) receptors serve as modulators of synaptic transmission in the
mammalian central nervous system (CNS) with both short-term and long-lasting effects 1 . …

The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are
important determinants of synaptic function, yet the neurotransmitter concentration time …

Activity-dependent synaptic rearrangements during CNS development require NMDA receptor
activation. The control of NMDA receptor function by developmentally regulated subunit …

SYNAPTIC release of glutamate results in a two component excitatory postsynaptic current (epsc)
at many vertebrate central synapses 1–6 . Non-N-methyl-D-aspartate receptors …

Westudied the roleof desensitization at inhibitory synapses by comparing nonequilibrium
GABAI channel gating with inhibitory postsynaptic currents (IPSCs). Currents activated by brief …

A change in the probability of neurotransmitter release (P r ) is an important mechanism
underlying synaptic plasticity. Although P r is often assumed to be the same for all terminals at a …

The role of desensitization of ligand-gated channels at fast chemical synapses has been
difficult to establish. Desensitization has been studied traditionally with prolonged agonist …