The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during
apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation. The predominant site of …

p53 is a pivotal molecule regulating the death of neurons both after acute injury and during
development. The molecular mechanisms by which p53 induces apoptosis in neuronal cells, …

The reinforcing properties of cocaine can readily become associated with salient environmental
stimuli that acquire secondary reinforcing properties. This form of classical conditioning …

The molecular mechanisms mediating degeneration of midbrain dopamine neurons in
Parkinson's disease (PD) are poorly understood. Here, we provide evidence to support a role for …

Accumulating evidence strongly suggests that apoptosis contributes to neuronal cell death
in a variety of neurodegenerative contexts. Activation of the cysteine protease caspase‐3 …

Several molecules inhibit axonal growth cones and may account for the failure of central
nervous system regeneration, including myelin proteins and various chondroitan sulfate …

Clozapine and haloperidol produce different induction patterns of c-fos expression in the
forebrain, with haloperidol increasing Fos-like immunoreactivity (FLI) in the striatum, nucleus …

Hypoxia-ischemia (HI) in the developing brain results in brain injury with prominent features
of both apoptosis and necrosis. A peptide-based pan-caspase inhibitor is neuroprotective …

Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disorder characterized
by T cell mediated demyelination. In MS, prolonged T cell survival and increased T cell …

Although B-amyloid (AB) is suggested to play an important role in Alzheimer's disease, the
mechanisms that control AB-evoked toxicity are unclear. We demonstrated previously that the …