Objective Although the underlying cause of Huntington's disease (HD) is well established,
the actual pathophysiological processes involved remain to be fully elucidated. In other …

Objective Huntington disease (HD) is caused by a genetically encoded pathological protein
(mutant huntingtin [mHtt]), which is thought to exert its effects in a cell‐autonomous manner. …

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder of the
central nervous system (CNS) that is defined by a CAG expansion in exon 1 of the huntingtin …

Huntington’s disease is a neurodegenerative disorder caused by an abnormal CAG repeat
expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct …

In recent years, in vivo animal models of prenatal infection have been developed in an
attempt to recreate behavioral and neuropathological features associated to a number of …

Background: The application of low-intensity direct current electric fields has been experimentally
used in the clinic to treat a number of brain disorders, predominantly using transcranial …

The synthesis rates of n‐3 and n‐6 polyunsaturated fatty acids (PUFAs) in rodents and humans
are not agreed upon and depend on substrate availability independently of the capacity …

Tauopathies are a subclass of neurodegenerative diseases typified by the deposition of
abnormal microtubule-associated tau protein within the cerebral tissue. Alzheimer's disease, …

Cell replacement has been explored as a therapeutic strategy to repair the brain in patients
with Huntington’s and Parkinson’s disease. Post-mortem evaluations of healthy grafted …

In the Fifties, electron microscopy studies on neuronal cells showed that mitochondria typically
cluster at synaptic terminals, thereby introducing the concept that proper mitochondria …