Netrin-1 is a secreted protein that directs long-range axon guidance during early stages of
neural circuit formation and continues to be expressed in the mammalian forebrain during the …

Theoretical and in vivo neuroscience research suggests that functional information transfer
within neuronal networks is influenced by circuit architecture. Due to the dynamic …

The fundamental mechanisms of complex neural computation remain largely unknown,
especially in respect to the characteristics of distinct neural circuits within the mammalian brain. …

Implantable electronics address therapeutical needs of patients with electrical signaling
dysfunctions such as heart problems, neurological disorders or hearing impairments. While …

Arranging cultured cells in patterns via surface modification is a tool used by biologists to
answer questions in a specific and controlled manner. In the past decade, bottom-up …

The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon
guidance during development and are expressed by neurons in the mature brain. Netrin-1 …

Bottom-up neuroscience aims to engineer well-defined networks of neurons to investigate
the functions of the brain. By reducing the complexity of the brain to achievable target …

Interactions with local extracellular cues direct cell migration. A versatile method to study cell
response to a protein consists of patterning the protein cue on a substrate and quantifying …

Three-dimensional (3D) cell culture models are gaining increasing interest for use in drug
development pipelines due to their closer resemblance to human tissues. Hydrogels are the …

The amyloid precursor protein ( APP ) and its paralogs, amyloid precursor‐like protein 1 (APLP1)
and APLP 2, are metalloproteins with a putative role both in synaptogenesis and in …