User profiles for H M Vargas
 | Hugo M. VargasExecutive Director, Translational Safety & Pharmacology, Amgen, Inc Verified email at amgen.com Cited by 3855 |
Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative
In October 2008, in a public forum organized by the Cardiac Safety Research Consortium
and the Health and Environmental Sciences Institute, leaders from government, the …
and the Health and Environmental Sciences Institute, leaders from government, the …
Time for a fully integrated nonclinical–clinical risk assessment to streamline QT prolongation liability determinations: A pharma industry perspective
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc)
prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of …
prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of …
Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics
HM Vargas, AS Bass, A Breidenbach… - … of pharmacological and …, 2008 - Elsevier
Biological therapeutic agents (biologicals), such as monoclonal antibodies (mAbs), are
increasingly important in the treatment of human disease, and many types of biologicals are in …
increasingly important in the treatment of human disease, and many types of biologicals are in …
[PDF][PDF] Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.
…, V Wolf, RW Kosley, L Davis, HM Vargas - … of Pharmacology and …, 1996 - researchgate.net
Acetylcholinesterase(AChE) inhibitors from several chemical classes have been tested for
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …
the symptomatic treatment of Alzheimer’s disease; however, the therapeutic success of these …
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
…, MJ Marino, VK Graufelds, HM Vargas… - Journal of medicinal …, 2008 - ACS Publications
The novel T-type antagonist (S)-5 has been prepared and evaluated in in vitro and in vivo
assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 …
assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 …
Proarrhythmia risk assessment in human induced pluripotent stem cell-derived cardiomyocytes using the maestro MEA platform
Y Qu, HM Vargas - Toxicological Sciences, 2015 - academic.oup.com
Abstract Evaluation of stem cell-derived cardiomyocytes (SC-CM) using multi-electrode
array (MEA) has attracted attention as a novel model to detect drug-induced arrhythmia. An …
array (MEA) has attracted attention as a novel model to detect drug-induced arrhythmia. An …
Key characteristics of cardiovascular toxicants
…, NG Posnack, HM Vargas… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards. …
called key characteristics (KCs) was first developed to identify carcinogenic hazards. …
The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative
…, A Teisman, K Van Ammel, HM Vargas… - Toxicological …, 2014 - academic.oup.com
It is widely accepted that more needs to be done to bring new, safe, and efficacious drugs to
the market. Cardiovascular toxicity detected both in early drug discovery as well as in the …
the market. Cardiovascular toxicity detected both in early drug discovery as well as in the …
Safety pharmacology investigations on the nervous system: An industry survey
…, J Stevens, JP Valentin, HM Vargas… - … of pharmacological and …, 2016 - Elsevier
The Safety Pharmacology Society (SPS) conducted an industry survey in 2015 to identify
industry practices as they relate to central, peripheral and autonomic nervous system (‘CNS’) …
industry practices as they relate to central, peripheral and autonomic nervous system (‘CNS’) …
Phenyl-substituted analogs of oxotremorine as muscarinic antagonists
BM Nilsson, HM Vargas, B Ringdahl… - Journal of medicinal …, 1992 - ACS Publications
Method B. Stannane 10 (173 mg, 0.5 mmol) in 5 mL of CH2C12 was reacted with iodine (127
mg, 0.5 mmol) as described for 8. The dried CH2C12 was removed in vacuo to give 152 …
mg, 0.5 mmol) as described for 8. The dried CH2C12 was removed in vacuo to give 152 …