Classical benzodiazepine drugs are in wide clinical use as anxiolytics, hypnotics, anticonvulsants,
and muscle relaxants. They act by enhancing the γ-aminobutyric acid A (GABA A ) …

Because of its control of spike-timing and oscillatory network activity, γ-aminobutyric acid (GABA)-ergic
inhibition is a key element in the central regulation of somatic and mental …

In the regulation of behavior, the role of GABA neurons has been extensively studied in the
circuit of fear, where GABA interneurons play key parts in the acquisition, storage and …

Benzodiazepines produce most, if not all, of their numerous effects on the central nervous
system (CNS) primarily by increasing the function of those chemical synapses that use γ-…

… 10 nM [ 3 H]Ro15-4513 in the presence of 100 μM diazepam to reveal the diazepam-insensitive
[ 3 H]Ro15-4513 binding sites. In wild-type mice, diazepam-insensitive [ 3 H]Ro15-4513 …

… The latency for reentering the dark compartment 24 h later was shortened in wildtype (U ¼
… the latency to re-enter the dark compartment 24 h after training in wild-type mice but not in 1(…

The heterogeneity of γ-aminobutyric acid type A (GABA A ) receptors contributes to the diversity
of neuronal inhibition in the regulation of information processing. Although most GABA A …

… a, Effects of administration of L-838,417 (arrowed) on thermal hyperalgesia 6 h after injection
… Heat hyperalgesia was assessed 24 h and 6 h after induction of inflammation in mice and …

… The cells were pretreated with 0.2% Triton X-100 for 1 h and then incubated for 3 days in
rabbit anti-glucagon (Novo, Sweden), rabbit anti-somatostatin (Bio-Bol, Sweden) antibodies …

The effects of several benzodiazepines on a variety of nervous activities known or presumed
to depend on GABA are presented and compared with those of agents that deplete or …